Currently you can only optimize the whole run which is fine to get the basic layout. The run optimize will be 70% in the right order and you might have to flip the run to cater for adhoc constraints.
For example: If you had the ability to optimise individual sections of the run, order a few consignments manually after that optimised section, then optimize the second part of the run, that would save you having to move each individual consignment into the correct order. I could spend up to 20 minutes per runsheet for a 50 drop run, individually moving each consignment because it routed in a backwards order.